When using marijuana, the following occur: impaired coordination of movements, increased reaction time, weakening of oculomotor functions, impaired depth of vision and color perception. Angioneuropathy of the retina and optic nerves is possible.
As a result of long-term marijuana use, numerous and varied somatic pathologies are formed.
The cardiotoxic effect of marijuana is known. Changes in atrioventricular conduction, sinus tachy- or bradyarrhythmia (heart rhythm disturbances), extrasystoles, arterial hypo- or hypertension observed in marijuana users can be explained by a number of factors: disruption of central regulation, changes in sympathetic tone and vagus tone, metabolic and neurochemical (mediator) changes in the myocardium. In addition, long-term marijuana users often develop angina pectoris and myocardial dystrophy.
Since the dominant method of marijuana use is smoking, patients often suffer from pathology of the lungs and upper respiratory tract. Already during the examination, signs of chronic nasopharyngitis, stomatitis and glossitis are noticeable: nasal congestion, swelling and hyperemia of the uvula, change in the color of the tongue. The anamnesis reveals frequent upper respiratory tract infections, chronic non-specific lung diseases. Like any smoking, smoking hashish is a risk factor for lung cancer.
Long-term marijuana use leads to severe disruptions of endocrine functions. A decrease in libido and feelings of sexual satisfaction are often observed. Cases of hypogonadism are known. In men, due to a decrease in testosterone synthesis, potency decreases and gynecomastia develops. In women, menstrual irregularities are observed, up to a complete absence of menstruation, as well as reproductive dysfunction, up to complete infertility. In addition, non-specific hepatitis is common, leading to liver atrophy, renal failure.
Mortality from marijuana use is determined by cardiac dysregulation and pulmonary diseases, in particular, infectious ones. The high frequency of infectious diseases is due to the suppression of cellular immunity, blastogenesis, and a decrease in the number of T-lymphocytes.
When marijuana is used by pregnant women, fetal developmental disorders and perinatal pathology are very likely. Cannabinoids easily penetrate the placental barrier into the fetus's blood and, as has been shown in animal experiments, can have a teratogenic effect (promoting the development of fetal malformations). In addition, cannabinoids can cause pathology of the nervous system and visual organs of the unborn child
The use of marijuana by pregnant women is a risk factor for spontaneous abortions and premature births. At the same time, the birth itself in women who use marijuana can be complicated by weak labor with all the ensuing consequences. In newborns exposed to cannabinoids in utero, meconium staining occurs more often and is more pronounced than in children of healthy mothers.
It is also known that when a nursing woman smokes hashish, the concentration of cannabinoids in her breast milk is significantly higher than in blood plasma. Therefore, the damaging effects of cannabinoids on the child of such a woman will continue after birth.
Since the dominant method of using cannabinoids is smoking, then in addition to the effects specific to these drugs, the fetus, and then the child of a woman who smokes hashish, will suffer from all the non-specific consequences associated with this method of use